SnapShot: Reactive Oxygen Intermediates (ROI)
نویسندگان
چکیده
منابع مشابه
Regulation of cytokine gene expression by reactive oxygen and reactive nitrogen intermediates.
Reactive oxygen intermediates (ROI), reactive nitrogen intermediates (RNI), and cytokines are frequent companions at sites of acute inflammation. Previous work has established a clear link between the production of cytokines and the subsequent generation of ROI and RNI. However, more recent data indicates that ROI and RNI not only serve as end-stage effector molecules of pathogen destruction an...
متن کاملReactive nitrogen intermediates have a bacteriostatic effect on Mycobacterium tuberculosis in vitro.
Susceptibility of six isolates of Mycobacterium tuberculosis (CB3.3, CDC1551, RJ2E, C.C.13, H37Rv, and H37Ra) and two isolates of Mycobacterium bovis (Ravenel and BCG) to reactive oxygen intermediates (ROI) and reactive nitrogen intermediates (RNI) was determined by standard in vitro survival assays. After 21 days of incubation, the survival of most strains exposed to either acidified sodium ni...
متن کاملArabidopsis gp91phox homologues AtrbohD and AtrbohF are required for accumulation of reactive oxygen intermediates in the plant defense response.
Reactive oxygen intermediates (ROI) are strongly associated with plant defense responses. The origin of these ROI has been controversial. Arabidopsis respiratory burst oxidase homologues (rboh genes) have been proposed to play a role in ROI generation. We analyzed lines carrying dSpm insertions in the highly expressed AtrbohD and AtrbohF genes. Both are required for full ROI production observed...
متن کاملLocalized reactive oxygen and nitrogen intermediates inhibit escape of Listeria monocytogenes from vacuoles in activated macrophages.
Listeria monocytogenes (Lm) evades being killed after phagocytosis by macrophages by escaping from vacuoles into cytoplasm. Activated macrophages are listericidal, in part because they can retain Lm in vacuoles. This study examined the contribution of reactive oxygen intermediates (ROI) and reactive nitrogen intermediates (RNI) to the inhibition of Lm escape from vacuoles. Lm escaped from vacuo...
متن کاملReactive Oxygen Intermediates Activate NF - KB in a Tyrosine Kinase - Dependent Mechanism and in Combination With Vanadate Activate the ~ 5 6 ’ ‘ ~ and ~ 5 9 ‘ ~ ” Tyrosine Kinases in Human Lymphocytes
We have previously observed that ionizing radiation induces tyrosine phosphorylation in human B-lymphocyte precursors by stimulation of unidentified tyrosine kinases and this phosphorylation is substantially augmented by vanadate. Ionizing radiation generates reactive oxygen intermediates (ROI). Because HzO, is a potent ROI generator that readily crosses the plasma membrane, we used H,O, to exa...
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ورودعنوان ژورنال:
- Cell
دوره 140 شماره
صفحات -
تاریخ انتشار 2010